Paroxetine but not imipramine improved depression related outcomes in adolescents with DSM-IV major depression.

Patients 275 adolescents (mean age 15 y, 62% girls) who were medically healthy with a current episode of DSM-IV major depression for >8 weeks. Additional inclusion criteria were a total score of >12 on the Hamilton Depression Rating Scale (HDRS), a score of < 60 on the Children’s Global Assessment Scale, and a score of >80 on the Peabody Picture Vocabulary Test. Exclusion criteria included a current or lifetime DSM-IV diagnosis of bipolar disorder, schizoaffective disorder, eating disorder, alcohol or substance use disorder, and organic brain disorder. 99% of patients were included in the analysis.